Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049787 | 0.88 | TPH1 (0.49) | TPH1VCPGPR119CKS1BSKP1 | |
| SCHEMBL4562339 | 0.86 | GPR119 (0.49) | TPH1VCPGPR119TSHR | |
| SCHEMBL4055884 | 0.84 | GPR119 (0.59) | TPH1GPR119 | |
| SCHEMBL13690743 | 0.83 | VCP (0.48) | TPH1VCPGPR119CKS1BSKP1 | |
| SCHEMBL4566452 | 0.83 | GPR119 (0.61) | TPH1VCPGPR119 | |
| SCHEMBL13690387 | 0.83 | GPR119 (0.59) | GPR119 | |
| SCHEMBL4055083 | 0.82 | GPR119 (0.44) | GPR119PTGS2PTGS1 | |
| SCHEMBL4051025 | 0.81 | GPR119 (0.47) | TPH1GPR119CKS1BSKP1SKP2 | |
| SCHEMBL4053708 | 0.81 | NPY2R (0.48) | TPH1VCPGPR119CKS1BSKP1 | |
| SCHEMBL13690452 | 0.80 | LMNA (0.43) | TPH1VCPGPR119CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |