Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 3/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690524 | 0.88 | PRMT5 (0.46) | TPH1KDM4E | |
| SCHEMBL4049787 | 0.87 | TPH1 (0.49) | TPH1GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4234932 | 0.84 | TPH1 (0.49) | TPH1GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4050033 | 0.84 | TPH1 (0.53) | TPH1GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4048278 | 0.81 | LIPE (0.38) | GRIN2BACHE | |
| SCHEMBL4371541 | 0.81 | TPH1 (0.48) | TPH1GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4373471 | 0.81 | ATR (0.50) | TPH1GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4057216 | 0.77 | IKBKB (0.48) | TPH1 | |
| SCHEMBL4370900 | 0.77 | IKBKB (0.48) | TPH1 | |
| SCHEMBL3986034 | 0.77 | GPR119 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |