Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | PREP | P48147 | 2/20 | 0.30 |
| ▸ | FAP | Q12884 | 2/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046790 | 0.89 | USP30 (0.36) | CTSKCTSSCTSLUSP30CTSB | |
| SCHEMBL4041529 | 0.89 | CTSK (0.47) | CTSKCTSSCTSLALDH1A1HSD17B10 | |
| SCHEMBL4050441 | 0.89 | CTSK (0.39) | CTSKCTSSCTSLALDH1A1HTT | |
| SCHEMBL4042558 | 0.89 | CTSK (0.39) | CTSKCTSSCTSLALDH1A1HTT | |
| SCHEMBL4047038 | 0.87 | CTSK (0.39) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4045248 | 0.86 | NPC1 (0.33) | CTSKCTSSCTSLUSP30ADAM17 | |
| SCHEMBL4044961 | 0.85 | CHRNB2 (0.35) | CTSKCTSSF12CTSBSMN1; SMN2 | |
| SCHEMBL4050728 | 0.82 | SMN1; SMN2 (0.33) | CTSKCTSSHTTHSD17B10CTSB | |
| SCHEMBL4040702 | 0.82 | CTSK (0.38) | CTSKCTSSCTSLUSP30ADAM17 | |
| SCHEMBL4043865 | 0.82 | CTSK (0.36) | CTSKCTSSCTSLUSP30L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |