Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038978 | 0.90 | USP30 (0.34) | CTSKHPGDCTSLCTSSTRPM8 | |
| SCHEMBL4042896 | 0.90 | CTSK (0.45) | CTSKHPGDCTSLCTSSTAS1R3 | |
| SCHEMBL4046175 | 0.89 | CTSK (0.37) | CTSKHPGDCTSLCTSSALDH1A1 | |
| SCHEMBL4039519 | 0.89 | CTSK (0.37) | CTSKHPGDCTSLCTSSALDH1A1 | |
| SCHEMBL4049501 | 0.88 | CTSK (0.40) | CTSKHPGDCTSLCTSSTRPM8 | |
| SCHEMBL4051635 | 0.86 | HPGD (0.37) | CTSKHPGDCTSLCTSSTRPM8 | |
| SCHEMBL4044847 | 0.85 | CHRNB2 (0.39) | CTSKHPGDCTSLCTSSTRPM8 | |
| SCHEMBL4043432 | 0.83 | KCNQ1 (0.38) | HPGDTRPM8USP30ALDH1A1MEN1 | |
| SCHEMBL4045412 | 0.82 | CTSK (0.48) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4050878 | 0.82 | CTSK (0.38) | CTSKCTSLCTSSUSP30ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |