Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406231 | 0.95 | DRD2 (0.47) | DRD2DRD3PARP1HTR1AHTR2A | |
| SCHEMBL30377833 | 0.95 | DRD2 (0.47) | DRD2DRD3PARP1HTR1AHTR2A | |
| SCHEMBL401463 | 0.89 | DRD2 (0.50) | DRD2DRD3PARP1HTR1AHTR3A | |
| SCHEMBL7478192 | 0.75 | PARP1 (0.52) | DRD2DRD3PARP1HTR1AHTR2A | |
| SCHEMBL4780239 | 0.71 | NOS3 (0.38) | HTR2AHTR2C | |
| SCHEMBL9204124 | 0.70 | DRD2 (0.57) | DRD2DRD3PARP1HTR1AHTR3A | |
| SCHEMBL9124998 | 0.69 | DRD2 (0.56) | DRD2DRD3PARP1HTR1AHTR3A | |
| SCHEMBL854184 | 0.69 | PARP1 (0.61) | DRD2DRD3PARP1HTR1AUSP2 | |
| SCHEMBL16584068 | 0.68 | DRD2 (0.41) | DRD2DRD3PARP1HTR1AFGFR1 | |
| SCHEMBL15828534 | 0.68 | NPC1 (0.37) | HTR2AHTR2CUSP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8092251-A | — | — | None | — | — | JP | disclosed |
| CN-112979543-B | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2024-09-24 | — | — | CN | disclosed |
| US-12071421-B2 | Process for the synthesis of substituted chloromethyl dialkylphosphates | HELSINN HEALTHCARE SA (CH) | 2024-08-27 | — | — | US | disclosed |
| US-20220401463-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | HELSINN HEALTHCARE SA (CH) | 2022-12-22 | — | — | US | disclosed |
| US-11312698-B2 | Fosnetupitant chloride hydrochloride having improved stability | HELSINN HEALTHCARE SA (CH) | 2022-04-26 | — | — | US | disclosed |
| CN-112979543-A | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-112961104-A | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2021-06-15 | — | — | CN | disclosed |
| US-20200399240-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | HELSINN HEALTHCARE SA (CH) | 2020-12-24 | — | — | US | disclosed |
| CN-111662330-A | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2020-09-15 | — | — | CN | disclosed |
| US-10717721-B2 | Substituted piperaziniums for the treatment of emesis | HELSINN HEALTHCARE SA (CH) | 2020-07-21 | — | — | US | disclosed |
| US-5563272-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5563272-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-10-08 | — | — | US | disclosed |
| JP-H0892251-A | 5,6-DIHYDRO-4H-IMIDAZO(4,5,1-IJ)QUINOLINES, THEIR PRODUCTION, USE THEREOF AS MEDICAMENT AND INTERMEDIATE COMPOUND | HOECHST ROUSSEL PHARMACEUT INC | 1996-04-09 | — | — | JP | disclosed |
| US-5500423-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| US-5500423-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| US-5500423-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0700913-A1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0700913-A1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0700913-A1 | 5,6-dihydro-4H-imidazo(4,5,1-ij)quinolines, processes for their preparation, their use as medicaments, and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0146370-B1 | IMIDAZOQUINOLINES CONTAINING OTHER HETEROCYCLIC GROUPS | JOHN WYETH & BROTHER LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312698-B2 | Fosnetupitant chloride hydrochloride having improved stability | FOS, FOSB, CLCN2 | DRD2 1030/4885DRD3 1640/4885PARP1 2702/4885 |
| US-20200399240-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | BDKRB2, BDKRB1, TACR1 | DRD2 1942/4885DRD3 2195/4885PARP1 3342/4885 |
| US-20220401463-A1 | SUBSTITUTED 4-PHENYL-PYRIDINES | BDKRB2, BDKRB1, TACR1 | DRD2 1942/4885DRD3 2195/4885PARP1 3342/4885 |
| US-12071421-B2 | Process for the synthesis of substituted chloromethyl dialkylphosphates | BDKRB1, BDKRB2, TK1 | DRD2 2109/4885DRD3 2314/4885PARP1 918/4885 |
| US-10717721-B2 | Substituted piperaziniums for the treatment of emesis | VIPR2, VIPR1, GRPR | DRD2 1264/4885DRD3 2280/4885PARP1 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.