Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 5/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054822 | 0.79 | NPC1 (0.41) | HPGDKDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL7985907 | 0.71 | L3MBTL1 (0.38) | ALDH1A1KDM4EHSD17B10MAPK1MEN1 | |
| SCHEMBL11360559 | 0.69 | CHRM1 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8221697 | 0.69 | GPR65 (0.48) | — | |
| SCHEMBL4046230 | 0.68 | BRAF (0.44) | MAPK1NPSR1MEN1KMT2ABRAF | |
| SCHEMBL1013875 | 0.67 | BRAF (0.62) | MEN1KMT2ABRAF | |
| SCHEMBL11368483 | 0.67 | GPR65 (0.34) | HPGDALDH1A1KDM4EMAPTNPSR1 | |
| SCHEMBL20425561 | 0.67 | TSHR (0.45) | MEN1TSHRKMT2AGAA | |
| SCHEMBL884784 | 0.66 | CHRM1 (0.42) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7993429 | 0.65 | CHRM2 (0.36) | HPGDALDH1A1KDM4EMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |