Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 11/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046230 | 0.82 | BRAF (0.44) | MEN1KMT2ABRAF | |
| SCHEMBL4051790 | 0.79 | HPGD (0.40) | MEN1KMT2ABRAFGAAKDM4E | |
| SCHEMBL4047488 | 0.78 | BRAF (0.67) | MEN1KMT2ABRAF | |
| SCHEMBL1013875 | 0.74 | BRAF (0.62) | NPC1RAB9AMEN1KMT2ABRAF | |
| SCHEMBL7986449 | 0.69 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2CYP2C19KDM4E | |
| SCHEMBL8221697 | 0.68 | GPR65 (0.48) | — | |
| SCHEMBL238859 | 0.68 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL884784 | 0.67 | CHRM1 (0.42) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20425643 | 0.65 | OPRM1 (0.40) | MEN1KMT2ACYP2C9CYP2C19CYP1A2 | |
| SCHEMBL2062840 | 0.65 | GRM5 (0.37) | MEN1KMT2ASMN1; SMN2GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |