Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11362297 | 0.94 | ALDH1A1 (0.35) | ALDH1A1MEN1GAAMAPTKMT2A | |
| SCHEMBL11360559 | 0.79 | CHRM1 (0.36) | GPR65GRM5CHRM1ALDH1A1MEN1 | |
| SCHEMBL8221697 | 0.74 | GPR65 (0.48) | GPR65GRM5CHRM1CHRM4CHRM5 | |
| SCHEMBL11360096 | 0.73 | POLB (0.34) | GRM5CHRM1ALDH1A1MEN1GAA | |
| SCHEMBL7985907 | 0.72 | L3MBTL1 (0.38) | GPR65CHRM1ALDH1A1MEN1GAA | |
| SCHEMBL11354670 | 0.72 | ALDH1A1 (0.32) | GRM5CHRM1ALDH1A1MEN1GAA | |
| SCHEMBL11358064 | 0.72 | CHRM1 (0.32) | GPR65GRM5CHRM1MEN1MAPT | |
| SCHEMBL884784 | 0.70 | CHRM1 (0.42) | GRM5CHRM1ALDH1A1MEN1KMT2A | |
| SCHEMBL20425643 | 0.70 | OPRM1 (0.40) | GRM5CHRM1ALDH1A1MEN1KMT2A | |
| SCHEMBL2062840 | 0.70 | GRM5 (0.37) | GRM5CHRM1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277472-A | 3,6-Disubstituted-5,7-(lower alkano)-5,6,7,8-tetrahydropyrido(4,3-C)pyridazines; their intermediates, preparation, antihypertensive use and compositions | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-07-07 | — | — | US | disclosed |