Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002202 | 0.84 | ALDH1A1 (0.52) | PTGS2KMT2AMEN1RGS12ALDH1A1 | |
| SCHEMBL2002181 | 0.81 | LMNA (0.52) | KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL2006203 | 0.73 | ALDH1A1 (0.49) | PTGS2KMT2AMEN1RGS12ALDH1A1 | |
| SCHEMBL2002307 | 0.73 | ALDH1A1 (0.49) | PTGS2KMT2AMEN1RGS12ALDH1A1 | |
| SCHEMBL2004746 | 0.73 | ALDH1A1 (0.49) | PTGS2KMT2AMEN1RGS12ALDH1A1 | |
| SCHEMBL6867612 | 0.71 | CCR2 (0.61) | CCR2PTGS2KMT2AALDH1A1MAPT | |
| SCHEMBL2004526 | 0.70 | ALDH1A1 (0.52) | PTGS2KMT2AMEN1RGS12ALDH1A1 | |
| Acetic Acid SCHEMBL3967081 | 0.70 | CCR2 (0.63) | CCR2PTGS2KMT2AMEN1RGS12 | |
| SCHEMBL2001360 | 0.70 | ALDH1A1 (0.52) | PTGS2KMT2AMEN1RGS12ALDH1A1 | |
| SCHEMBL2008092 | 0.70 | ALDH1A1 (0.52) | PTGS2KMT2AMEN1RGS12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | CCR2 2597/4885PTGS2 460/4885KMT2A 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.