Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055284 | 0.87 | CASP3 (0.36) | ALDH1A1MAPTPLA2G4AKMT2ATP53 | |
| SCHEMBL4058283 | 0.75 | MAPT (0.43) | ALDH1A1SMN1; SMN2MAPTPLA2G4ALTB4R | |
| SCHEMBL4026837 | 0.74 | MAPT (0.45) | ALDH1A1MAPTKMT2AMEN1F2RL3 | |
| SCHEMBL4030576 | 0.73 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTPLA2G4ALTB4R | |
| SCHEMBL4055213 | 0.73 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTPLA2G4ALTB4R | |
| SCHEMBL2873973 | 0.70 | MAPT (0.51) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL4051064 | 0.69 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL8844983 | 0.68 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL8749734 | 0.68 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTPOLBKMT2A | |
| SCHEMBL522321 | 0.67 | CASP1 (0.46) | ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |