Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526390 | 1.00 | KMT2A (0.41) | KMT2AMEN1EPHX1CNR2ACHE | |
| SCHEMBL1536750 | 0.98 | KMT2A (0.42) | KMT2AMEN1EPHX1CNR2ACHE | |
| SCHEMBL19640034 | 0.95 | EPHX1 (0.42) | KMT2AMEN1EPHX1ACHERAB9A | |
| SCHEMBL2722735 | 0.92 | EPHX1 (0.44) | EPHX1ACHERAB9AALDH1A1ATM | |
| SCHEMBL1739332 | 0.86 | MAPT (0.46) | KMT2AEPHX1ACHERAB9ANPC1 | |
| SCHEMBL2475114 | 0.84 | MAPT (0.43) | KMT2AEPHX1ACHERAB9ANPC1 | |
| SCHEMBL9551099 | 0.82 | CTSB (0.40) | KMT2AMEN1CNR2MAPTSMN1; SMN2 | |
| SCHEMBL11603045 | 0.81 | CTSL (0.38) | CNR2ALDH1A1CTSLCTSBCTSS | |
| SCHEMBL7963422 | 0.81 | EPHX1 (0.43) | KMT2AEPHX1ACHERAB9ANPC1 | |
| SCHEMBL4661585 | 0.80 | RAB9A (0.37) | KMT2AMEN1EPHX1ACHERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086958-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma LP (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2009027820-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (DE) | 2009-03-05 | — | — | WO | disclosed |