Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | UTRN | P46939 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054203 | 0.90 | GPR119 (0.49) | GPR119ALDH1A1MAPTALOX5PTPN2 | |
| SCHEMBL4059341 | 0.86 | GPR119 (0.43) | GPR119ALDH1A1ALOX5CCNE2CCNE1 | |
| SCHEMBL4059581 | 0.84 | VSIR (0.54) | GPR119ALDH1A1MAPTUTRNALOX5 | |
| SCHEMBL4054470 | 0.84 | ADORA1 (0.47) | GPR119ALDH1A1MAPTALOX5KDM4E | |
| SCHEMBL4055547 | 0.83 | GPR119 (0.43) | GPR119ALDH1A1MAPTALOX5CCNE2 | |
| SCHEMBL4061714 | 0.82 | ALOX5 (0.56) | GPR119ALDH1A1MAPTALOX5PIK3R1 | |
| SCHEMBL4051830 | 0.81 | RAB9A (0.55) | GPR119ALDH1A1MAPTALOX5KDM4E | |
| SCHEMBL4051901 | 0.81 | NPC1 (0.62) | GPR119ALDH1A1MAPTALOX5KDM4E | |
| SCHEMBL402504 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MAPTNOTUMPIK3R1PIK3CA | |
| SCHEMBL4050450 | 0.80 | NPC1 (0.58) | GPR119ALDH1A1MAPTUTRNCCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-20050101647-A1 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1460067-A1 | BICYCLIC DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Chemical Industries, Ltd. (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101647-A1 | Bicyclic derivative, its production and use | ABL1, SRC, PTK2B | GPR119 1677/4885ALDH1A1 3683/4885MAPT 4026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.