Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064685 | 0.78 | ALDH1A1 (0.46) | POLBTSHRALDH1A1KMT2ATRPM8 | |
| SCHEMBL4075667 | 0.78 | KDM4E (0.50) | ALDH1A1SLC6A2KMT2ALMNASMN1; SMN2 | |
| SCHEMBL5862092 | 0.77 | MEN1 (0.60) | POLBTSHRALDH1A1CHRM2ADRA2A | |
| SCHEMBL5641708 | 0.76 | LIPE (0.43) | POLBTSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL243741 | 0.76 | POLB (0.51) | POLBTSHRALDH1A1CHRM2ADRA2A | |
| SCHEMBL27841533 | 0.76 | NPC1 (0.44) | TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL6430248 | 0.75 | TRPM8 (0.59) | POLBALDH1A1KMT2AMEN1TRPM8 | |
| SCHEMBL4067161 | 0.74 | NOTUM (0.47) | POLBTSHRKMT2ALMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL11804810 | 0.74 | POLB (0.50) | POLBTSHRALDH1A1CHRM2ADRA2A | |
| SCHEMBL6644466 | 0.74 | CYP2D6 (0.46) | POLBTSHRALDH1A1CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |