Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL21134117 | 0.80 | THRB (0.91) | THRBTDP1KDM4ELMNAHTT | |
| SCHEMBL30488775 | 0.79 | THRB (1.00) | THRBTDP1KDM4ELMNAHTT | |
| SCHEMBL18759751 | 0.79 | THRB (0.50) | THRBTDP1KDM4EHTTPDK2 | |
| SCHEMBL4636492 | 0.79 | THRB (0.68) | THRBTDP1KDM4ELMNAHTT | |
| SCHEMBL11469925 | 0.79 | THRB (1.00) | THRBTDP1KDM4ELMNAHTT | |
| SCHEMBL66735 | 0.79 | THRB (1.00) | THRBTDP1KDM4ELMNAHTT | |
| Bromomethane SCHEMBL208217 | 0.78 | THRB (0.88) | THRBTDP1KDM4ELMNAHTT | |
| SCHEMBL12083408 | 0.77 | ALDH1A1 (0.57) | THRBTDP1KDM4ELMNAHTT | |
| SCHEMBL22767920 | 0.77 | THRB (0.65) | THRBTDP1KDM4ELMNAHTT | |
| Bromide SCHEMBL27743796 | 0.77 | THRB (0.95) | THRBTDP1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595975-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX | Corning Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| US-20120329865-A1 | MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF | CORNING INCORPORATED | 2012-12-27 | — | — | US | disclosed |
| EP-2519236-A2 | MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF | Corning Incorporated (US) | 2012-11-07 | — | — | EP | disclosed |
| US-20120022116-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX | CORNING INCORPORATED | 2012-01-26 | — | — | US | disclosed |
| WO-2012012278-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX | CORNING INCORPORATED (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2011081970-A2 | MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF | CORNING INCORPORATED (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022116-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX | GPR35, GPR65, GPR68 | THRB 528/4885TDP1 4013/4885KDM4E 4643/4885 |
| US-20120329865-A1 | MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF | KCNH2, KCNJ2, KCNH3 | THRB 629/4885TDP1 1626/4885KDM4E 1668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.