Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27842026 | 0.87 | ADRB1 (0.49) | ADRA2BADRB1ADRA2AADRB3ADRA2C | |
| SCHEMBL6491103 | 0.85 | CES2 (0.51) | ADRA2BPTGS2PTGS1CXCL8AKR1C3 | |
| SCHEMBL490576 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1CXCL8GABRA1GABRB2 | |
| SCHEMBL7102472 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1CXCL8GABRA1GABRB2 | |
| SCHEMBL153695 | 0.80 | PTGS2 (0.59) | PTGS2PTGS1CXCL8GABRA1GABRB2 | |
| SCHEMBL29237654 | 0.80 | PTGS2 (0.44) | ADRA2BPTGS2PTGS1CXCL8AKR1C3 | |
| SCHEMBL1679090 | 0.80 | CXCL8 (0.56) | PTGS2PTGS1CXCL8AKR1C3AKR1C2 | |
| SCHEMBL10687309 | 0.80 | PTGS2 (0.44) | ADRA2BPTGS2PTGS1CXCL8AKR1C3 | |
| SCHEMBL30967948 | 0.80 | PTGS2 (0.44) | ADRA2BPTGS2PTGS1CXCL8AKR1C3 | |
| SCHEMBL1261293 | 0.79 | PTGS2 (0.46) | ADRA2BPTGS2PTGS1CXCL8AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1666472-B1 | PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | ONO PHARMACEUTICAL CO (JP) | 2012-08-01 | — | — | EP | disclosed |
| US-7560475-B2 | Phenylacetic acid derivative, process for producing the same, and use | ONO PHARMACEUTICAL CO., LTD. (JP) | 2009-07-14 | — | — | US | disclosed |
| US-20070105868-A1 | Phenylacetic acid derivative, process for producing the same, and use | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| EP-1666472-A1 | PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105868-A1 | Phenylacetic acid derivative, process for producing the same, and use | PPARA, PPARD, PPARG | ADRA2B 31/4885ADRB1 7/4885ADRA2A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.