Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070096 | 0.91 | L3MBTL1 (0.35) | KCNN4MAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL4072684 | 0.90 | DRD2 (0.41) | KCNN4MAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL4071575 | 0.78 | DRD2 (0.59) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8828491 | 0.75 | HTR6 (0.63) | MAPTDRD2DRD3HTR3EHTR3B | |
| SCHEMBL19527583 | 0.75 | MAPT (0.52) | MAPTNPC1ALDH1A1RAB9ADRD2 | |
| Hydrochloric Acid SCHEMBL8828557 | 0.74 | LMNA (0.64) | MAPTDRD2DRD3HTR3EHTR3B | |
| SCHEMBL20129731 | 0.73 | MEN1 (0.41) | KCNN4MAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL28193355 | 0.73 | HTR6 (0.51) | MAPTDRD2DRD3HTR3EHTR3B | |
| SCHEMBL19527608 | 0.72 | APLNR (0.39) | KCNN4MAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL4072195 | 0.72 | SMN1; SMN2 (0.46) | MAPTALDH1A1SMN1; SMN2DRD3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |