Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072858 | 0.91 | KCNN4 (0.36) | KCNN4ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4072684 | 0.81 | DRD2 (0.41) | KCNN4ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4065094 | 0.80 | DRD2 (0.56) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4069218 | 0.74 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2MAPTDRD3CYP2C19 | |
| SCHEMBL19527583 | 0.73 | MAPT (0.52) | L3MBTL1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8828491 | 0.73 | HTR6 (0.63) | MAPTDRD2DRD3SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8828557 | 0.72 | LMNA (0.64) | MAPTDRD2DRD3SLC6A2SLC6A4 | |
| SCHEMBL4067061 | 0.72 | ALDH1A1 (0.42) | L3MBTL1ALDH1A1SMN1; SMN2MAPTSLC6A4 | |
| SCHEMBL4068610 | 0.72 | ADRB1 (0.48) | L3MBTL1ALDH1A1MAPTRAB9AADRA1D | |
| SCHEMBL4067558 | 0.72 | GALR2 (0.42) | ALDH1A1ADRB1GALR2GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |