SCHEMBL407595

SCHEMBL407595

O=C(O)c1ccc(C(O)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.56
DAO P14920 1/20 0.56
NAPRT Q6XQN6 1/20 0.56
TP53 P04637 1/20 0.55
SRD5A2 P31213 5/20 0.54
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54
TRPA1 O75762 1/20 0.48
KIF11 P52732 1/20 0.47
HDAC6 Q9UBN7 1/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
TYR P14679 1/20 0.46
DRD1 P21728 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8824291 0.90 SMN1; SMN2 (0.63) TSHRDAONAPRTTP53SRD5A2
SCHEMBL5311010 0.86 TSHR (0.56) TSHRDAONAPRTTP53SRD5A2
SCHEMBL3507435 0.86 CA12 (0.52) TSHRDAONAPRTTP53SRD5A2
SCHEMBL8824303 0.86 CA1 (0.67) CES2CES1CA1CA2ALOX15
SCHEMBL20721895 0.84 TSHR (0.59) TSHRDAONAPRTTP53SRD5A2
SCHEMBL18896444 0.84 TSHR (0.59) TSHRDAONAPRTTP53SRD5A2
SCHEMBL8346953 0.83 SRD5A2 (0.74) TSHRTP53SRD5A2CES2CES1
SCHEMBL8350483 0.83 BCL2L1 (0.63) TSHRTP53SRD5A2CES2CES1
SCHEMBL28014689 0.83 CYP2C9 (0.64) TSHRDAONAPRTTP53SRD5A2
SCHEMBL4595048 0.83 TSHR (0.71) TSHRTP53SRD5A2CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166696-B2 Solid phase synthesis supports and methods 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-01-23 US claimed
US-20040265899-A1 Solid phase synthesis supports and methods 3M INNOVATIVE PROPERTIES COMPANY 2004-12-30 US claimed
US-6787635-B2 azlactone-functionalized support such as a crosslinked polymer containing an alkenyl azlactone; use making combinatorial libraries 3M INNOVATIVE PROPERTIES COMPANY 2004-09-07 US claimed
EP-1373167-A2 SOLID PHASE SYNTHESIS SUPPORTS AND METHODS 3M Innovative Properties Company (US) 2004-01-02 EP claimed
US-20020173051-A1 Solid phase synthesis supports and methods 3M INNOVATIVE PROPERTIES COMPANY 2002-11-21 US claimed
WO-2002081078-A2 SOLID PHASE SYNTHESIS SUPPORTS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2002-10-17 WO claimed
EP-4741410-A1 SOLUBILIZATION GROUP FOR POORLY WATER-SOLUBLE PROTEINS Glytech, Inc. (JP) 2026-05-13 EP disclosed
US-20250122502-A1 Bifunctional Molecules and Methods of Using Thereof FLAGSHIP PIONEERING, INC. (US) 2025-04-17 US disclosed
US-20250114441-A1 POLYMERIC VACCINE FOR OPIOID ADDICTION THE JOHNS HOPKINS UNVERSITY 2025-04-10 US disclosed
US-20250090699-A1 FAP TARGETING CYCLIC PEPTIDES AND CONJUGATES THEREOF NOVARTIS AG (CH) 2025-03-20 US disclosed
WO-2025037249-A1 FAP TARGETING CYCLIC PEPTIDES AND CONJUGATES THEREOF NOVARTIS AG (CH) 2025-02-20 WO disclosed
US-20240400684-A1 ANTIBODY-MEDIATED DELIVERY OF CAS9 TO MAMMALIAN CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2024-12-05 US disclosed
US-20240173421-A1 MODULATION OF ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY SEAGEN INC. 2024-05-30 US disclosed
WO-2002006224-A1 PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-24 WO disclosed
WO-2001094946-A2 MICROARRAYS FOR PERFORMING PROTEOMIC ANALYSES CHIRON CORPORATION (US) 2001-12-13 WO disclosed
US-6228373-B1 PEPTIDE DIMER, GLYCINE, CYSTINE OR PROLNE AMINO ACID FOR IMMUNOLOGY ASTRA AKTIEBOLAG (SE) 2001-05-08 US disclosed
US-5922890-A TRITYL AMIDE OR ACID LINKERS FOR SOLID PHASE SYNTHESIS NOVARTIS AG (CH) 1999-07-13 US disclosed
EP-0785945-A1 NEW PEPTIDES WITH IMMUNOMODULATORY EFFECTS Astra Aktiebolag (SE) 1997-07-30 EP disclosed
US-5612474-A ANTIBODIES AND IMMUNOLOGY ELI LILLY AND COMPANY (US) 1997-03-18 US disclosed
WO-1996030397-A1 NEW PEPTIDES WITH IMMUNOMODULATORY EFFECTS ASTRA AKTIEBOLAG (SE) 1996-10-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250090699-A1 FAP TARGETING CYCLIC PEPTIDES AND CONJUGATES THEREOF FAP, FIBP, FGF23 TSHR 1413/4885DAO 2508/4885NAPRT 1182/4885
US-20020173051-A1 Solid phase synthesis supports and methods FES, LSS, CCNK TSHR 3025/4885DAO 1003/4885NAPRT 2396/4885
US-20040265899-A1 Solid phase synthesis supports and methods FES, LSS, CCNK TSHR 3025/4885DAO 1003/4885NAPRT 2396/4885
US-20250114441-A1 POLYMERIC VACCINE FOR OPIOID ADDICTION OPRM1, OPRK1, OPRL1 TSHR 1132/4885DAO 2504/4885NAPRT 792/4885
US-20240173421-A1 MODULATION OF ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY CD47, CD2, SSB TSHR 1004/4885DAO 3925/4885NAPRT 4430/4885
US-20250122502-A1 Bifunctional Molecules and Methods of Using Thereof EFTUD2, DDX21, SNRPE TSHR 3164/4885DAO 2575/4885NAPRT 2195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.