Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083540 | 0.85 | FGFR1 (0.50) | FYNCDK2CCNA2CCNA1NPC1 | |
| SCHEMBL4088455 | 0.83 | AURKA (0.47) | HPGDKCNK3KCNK9GRM5NPC1 | |
| SCHEMBL4092896 | 0.82 | HDAC6 (0.51) | CDK2CCNA2CCNA1NPC1RAB9A | |
| SCHEMBL3879252 | 0.82 | GPR35 (0.45) | KCNK3KCNK9CDK2CCNA2CCNA1 | |
| SCHEMBL4088586 | 0.81 | KCNK3 (0.42) | KCNK3KCNK9LCKPARP1GSK3B | |
| SCHEMBL4081310 | 0.79 | GPR35 (0.52) | CDK2CCNA2CCNA1GSK3BNPC1 | |
| SCHEMBL4088257 | 0.79 | AURKA (0.47) | KCNK3FYNCDK2CCNA2CCNA1 | |
| SCHEMBL4088652 | 0.79 | JAK2 (0.49) | KCNK3KCNK9CDK2CCNA2CCNA1 | |
| SCHEMBL4088594 | 0.79 | GPR35 (0.55) | CDK2CCNA2CCNA1NPC1RAB9A | |
| SCHEMBL4078387 | 0.79 | MAPK1 (0.48) | KCNK3KCNK9HDAC1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |