Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083540 | 0.86 | FGFR1 (0.50) | GPR35CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4092896 | 0.85 | HDAC6 (0.51) | GPR35CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL3879252 | 0.85 | GPR35 (0.45) | GPR35CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4085444 | 0.83 | AURKA (0.47) | GPR35CDK2CDC7DAPK3ROCK2 | |
| SCHEMBL4088594 | 0.82 | GPR35 (0.55) | GPR35CDK2CDK7AURKACCNA2 | |
| SCHEMBL4081022 | 0.81 | FLT3 (0.50) | GPR35FLT3NPC1RAB9AHDAC6 | |
| SCHEMBL4082126 | 0.79 | HDAC6 (0.48) | GPR35PIM1NPC1RAB9AGSK3B | |
| SCHEMBL4078664 | 0.79 | HPGD (0.44) | GPR35CDK2CDK7CCNA2CCNA1 | |
| SCHEMBL4088586 | 0.79 | KCNK3 (0.42) | GPR35AURKALRRK2RAB9AGSK3B | |
| SCHEMBL2913699 | 0.79 | GPR35 (0.51) | GPR35CDK7ALDH1A1PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |