Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083540 | 0.85 | FGFR1 (0.50) | RAB9AFGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL4078750 | 0.83 | AURKA (0.45) | KCNK3KCNK9PARP1ADORA3ADORA2A | |
| SCHEMBL4092896 | 0.82 | HDAC6 (0.51) | RAB9AADORA3ADORA2AHDAC6GPR35 | |
| SCHEMBL3879252 | 0.82 | GPR35 (0.45) | KCNK3KCNK9RAB9AFGFR1FGFR2 | |
| SCHEMBL4078664 | 0.81 | HPGD (0.44) | KCNK3KCNK9PARP1RAB9AGSK3B | |
| SCHEMBL4086303 | 0.80 | MAPK1 (0.49) | KCNK3KCNK9RAB9AADORA1ADORA3 | |
| SCHEMBL4088652 | 0.79 | JAK2 (0.49) | KCNK3KCNK9RAB9AADORA1GSK3B | |
| SCHEMBL4081310 | 0.79 | GPR35 (0.52) | RAB9AGSK3BLRRK2HDAC6GPR35 | |
| SCHEMBL4088257 | 0.79 | AURKA (0.47) | KCNK3RAB9AFGFR1FGFR3AURKA | |
| SCHEMBL4088594 | 0.79 | GPR35 (0.55) | RAB9AHDAC6GPR35AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |