SCHEMBL4079103

SCHEMBL4079103

C=CCNC(=O)N1CC(OC(c2ccc(OC(F)F)cc2)c2ccccc2C(F)(F)F)C1

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 2/20 0.37
CNR1 P21554 3/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
FAAH O00519 12/20 0.34
CNR2 P34972 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5803251 0.91 MEN1 (0.37) RBP4MEN1NPC1RAB9AKMT2A
SCHEMBL4088458 0.89 CNR1 (0.47) CNR1FAAHCNR2
SCHEMBL5801936 0.87 RBP4 (0.38) RBP4CNR1KMT2AFAAHCNR2
SCHEMBL4079397 0.85 RBP4 (0.40) RBP4CNR1FAAHCNR2
SCHEMBL29574824 0.84 CNR1 (0.48) RBP4CNR1FAAH
SCHEMBL4075637 0.84 CNR1 (0.48) RBP4CNR1FAAH
SCHEMBL4089334 0.83 CNR1 (0.40) RBP4CNR1FAAHCNR2
SCHEMBL4084837 0.82 CNR1 (0.51) RBP4CNR1FAAHCNR2
SCHEMBL4087335 0.77 HTT (0.44) CNR1FAAHCNR2
SCHEMBL4075594 0.77 RORC (0.45) RBP4CNR1MEN1KMT2AFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP claimed
US-7504522-B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMITED (GB) 2009-03-17 US claimed
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMAITED (GB) 2007-03-08 US claimed
EP-1620395-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2006-02-01 EP claimed
WO-2004096763-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2004-11-11 WO claimed
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2024-01-04 US disclosed
WO-2022109043-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. (US) 2022-05-27 WO disclosed
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2022-05-19 US disclosed
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2022-05-19 US disclosed
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose ANEBULO PHARMACEUTICALS, INC. (US) 2021-10-12 US disclosed
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose ANEBULO PHARMACEUTICALS, INC. (US) 2021-10-12 US disclosed
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP disclosed
US-7504522-B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMITED (GB) 2009-03-17 US disclosed
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMAITED (GB) 2007-03-08 US disclosed
EP-1620395-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2006-02-01 EP disclosed
WO-2004096763-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2004-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders CNR1, CNR2, GPR119 RBP4 2267/4885CNR1 1/4885MEN1 2044/4885
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH RBP4 3417/4885CNR1 1/4885MEN1 2789/4885
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH RBP4 3417/4885CNR1 1/4885MEN1 2789/4885
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose CNR1, CNR2, FAAH RBP4 3417/4885CNR1 1/4885MEN1 2789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.