Sugi Predict

Sugi Predict / Compounds / SCHEMBL407918

SCHEMBL407918

SCHEMBL407918

FC(F)(F)c1ccc2n[c]oc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 0.41
▸ BACE1 P56817 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ EPHX2 P34913 3/20 0.38
▸ SCN4A P35499 1/20 0.38
▸ NPBWR1 P48145 3/20 0.34
▸ PIM1 P11309 2/20 0.33
▸ PIM3 Q86V86 1/20 0.33
▸ CCNE2 O96020 1/20 0.33
▸ CCNA2 P20248 1/20 0.33
▸ CCNE1 P24864 1/20 0.33
▸ CDK2 P24941 1/20 0.33
▸ CCNA1 P78396 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ DGAT1 O75907 1/20 0.33
▸ KCNH2 Q12809 1/20 0.33
▸ PIM2 Q9P1W9 1/20 0.33
▸ PARP1 P09874 1/20 0.33
▸ GPR3 P46089 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL407727 0.85 PKM (0.45) PKMBACE1KDM4EEPHX2SCN4A
SCHEMBL11784333 0.81 SCN10A (0.36) PKMMEN1KMT2AKCNH2METAP2
SCHEMBL209566 0.75 KDM4E (0.34) PKMBACE1KDM4EMEN1KMT2A
SCHEMBL207175 0.71 BACE1 (0.34) BACE1PIM1PIM3MEN1KMT2A
SCHEMBL28056267 0.68 KDM4E (0.49) PKMBACE1KDM4EEPHX2SCN4A
SCHEMBL10497214 0.67 GAA (0.41) BACE1KDM4EMEN1KMT2A
SCHEMBL19914273 0.67 ALDH1A1 (0.56) BACE1KDM4EEPHX2SCN4ANPBWR1
SCHEMBL208752 0.67 MAP3K14 (0.33) —
SCHEMBL6411255 0.67 NPC1 (0.36) PKMMEN1KMT2AKCNH2
SCHEMBL18755165 0.66 BACE1 (0.42) BACE1KDM4EEPHX2SCN4ANPBWR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 — — EP claimed
EP-2387569-B1 HERBCIDES SYNGENTA LTD (GB) 2016-06-15 — — EP claimed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 — — US claimed
US-8865623-B2 Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds SYNGENTA LIMITED (GB) 2014-10-21 — — US claimed
CN-110997661-B Cyclopropyl ureaplatin 2 receptor and formyl peptide 1 receptor agonists 百时美施贵宝公司 2023-03-31 — — CN disclosed
US-11180490-B2 Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2021-11-23 — — US disclosed
EP-3634958-B1 CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-07-21 — — EP disclosed
US-20200199113-A1 CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-06-25 — — US disclosed
EP-3634958-A1 CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2020-04-15 — — EP disclosed
CN-110997661-A Cyclopropyl ureaplatin 2 receptor and formyl peptide 1 receptor agonists 百时美施贵宝公司 2020-04-10 — — CN disclosed
WO-2018227067-A1 CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-12-13 — — WO disclosed
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 — — EP disclosed
US-8680339-B2 Herbicides SYNGENTA LIMITED (GB) 2014-03-25 — — US disclosed
EP-2694495-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-02-12 — — EP disclosed
WO-2012136603-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-10-11 — — WO disclosed
US-20120253035-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-10-04 — — US disclosed
US-20120028800-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-02-02 — — US disclosed
US-20120021912-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 — — US disclosed
US-20120021909-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 — — US disclosed
US-20120021907-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11180490-B2 Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists FPR1, FPR2, FPR3 PKM 3985/4885BACE1 1647/4885KDM4E 4709/4885
US-20120021912-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 PKM 2307/4885BACE1 1901/4885KDM4E 1092/4885
US-20120253035-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS BACE2, BACE1, PSEN2 PKM 3826/4885BACE1 2/4885KDM4E 1734/4885
US-20200199113-A1 CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS FPR1, FPR2, FPR3 PKM 3985/4885BACE1 1647/4885KDM4E 4709/4885
US-20120021909-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 PKM 2307/4885BACE1 1901/4885KDM4E 1092/4885
US-20120021907-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 PKM 2307/4885BACE1 1901/4885KDM4E 1092/4885
US-20120028800-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 PKM 2307/4885BACE1 1901/4885KDM4E 1092/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.