SCHEMBL4079967

SCHEMBL4079967

O=C(NC12CC3CC(CC(C3)C1)C2)N1CC(OC(c2ccccc2Cl)c2ccccc2Cl)C1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.51
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HSD17B10 Q99714 1/20 0.46
LMNA P02545 4/20 0.45
HTT P42858 3/20 0.45
NPSR1 Q6W5P4 2/20 0.45
TSHR P16473 1/20 0.45
ALOX12 P18054 1/20 0.45
USP2 O75604 2/20 0.43
BCHE P06276 1/20 0.42
EPHX2 P34913 6/20 0.41
GAA P10253 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HPGD P15428 1/20 0.41
FAAH O00519 1/20 0.40
CNR1 P21554 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24454997 0.93 CNR2 (0.44) CNR2KDM4EALDH1A1HSD17B10LMNA
SCHEMBL23912852 0.83 OPRM1 (0.37) CNR2EPHX2FAAH
SCHEMBL4189467 0.82 LMNA (0.51) CNR2KDM4EALDH1A1HSD17B10LMNA
SCHEMBL4075603 0.82 LMNA (0.52) CNR2KDM4EALDH1A1LMNAHTT
SCHEMBL4075138 0.80 FAAH (0.43) CNR2LMNAHTTNPSR1TSHR
SCHEMBL4189090 0.78 FAAH (0.64) CNR2FAAHCNR1
SCHEMBL24433946 0.78 FAAH (0.34) LMNAHTTNPSR1TSHRALOX12
SCHEMBL4075655 0.78 CNR1 (0.51) FAAHCNR1
SCHEMBL4084625 0.77 CNR2 (0.47) CNR2KDM4EALDH1A1HSD17B10LMNA
SCHEMBL5746449 0.77 FAAH (0.49) CNR2LMNAHTTNPSR1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP claimed
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2024-01-04 US disclosed
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2022-05-19 US disclosed
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose ANEBULO PHARMACEUTICALS, INC. (US) 2021-10-12 US disclosed
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose ANEBULO PHARMACEUTICALS, INC. (US) 2021-10-12 US disclosed
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP disclosed
US-7504522-B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMITED (GB) 2009-03-17 US disclosed
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMAITED (GB) 2007-03-08 US disclosed
EP-1620395-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2006-02-01 EP disclosed
WO-2004096763-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2004-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders CNR1, CNR2, GPR119 CNR2 2/4885KDM4E 737/4885ALDH1A1 1099/4885
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH CNR2 2/4885KDM4E 1277/4885ALDH1A1 3052/4885
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH CNR2 2/4885KDM4E 1277/4885ALDH1A1 3052/4885
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose CNR1, CNR2, FAAH CNR2 2/4885KDM4E 1277/4885ALDH1A1 3052/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.