SCHEMBL4084625

SCHEMBL4084625

O=C(NC12CC3CC(CC(C3)C1)C2)N1CC(OC(c2ccc(Br)cc2)c2ccc(Br)cc2)C1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.47
EPHX2 P34913 5/20 0.44
POLB P06746 2/20 0.44
ALDH1A1 P00352 3/20 0.43
MAPT P10636 1/20 0.43
LMNA P02545 4/20 0.42
GAA P10253 1/20 0.42
USP2 O75604 1/20 0.42
NAAA Q02083 1/20 0.42
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
FKBP1A P62942 1/20 0.41
HTT P42858 2/20 0.41
HSD17B10 Q99714 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.39
ALOX12 P18054 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24454992 0.92 CNR2 (0.40) CNR2EPHX2POLBALDH1A1MAPT
SCHEMBL4075603 0.88 LMNA (0.52) CNR2EPHX2ALDH1A1MAPTLMNA
SCHEMBL23912878 0.82 SLC6A4 (0.38) EPHX2POLBALDH1A1MAPTNAAA
SCHEMBL23912853 0.81 LMNA (0.47) CNR2EPHX2LMNAGAAHTT
SCHEMBL4182411 0.80 LMNA (0.51) CNR2EPHX2ALDH1A1LMNAGAA
SCHEMBL4182413 0.80 LMNA (0.51) CNR2EPHX2ALDH1A1LMNAGAA
SCHEMBL4080235 0.77 FAAH (0.42) CNR2LMNAHTTTSHRALOX12
SCHEMBL4079967 0.77 CNR2 (0.51) CNR2EPHX2ALDH1A1LMNAGAA
SCHEMBL24433940 0.77 NAAA (0.38) ALDH1A1GAANAAAKDM4ESMN1; SMN2
SCHEMBL4078442 0.77 NAAA (0.46) POLBALDH1A1GAANAAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2024-01-04 US disclosed
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE ANEBULO PHARMACEUTICALS, INC. 2022-05-19 US disclosed
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose ANEBULO PHARMACEUTICALS, INC. (US) 2021-10-12 US disclosed
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP disclosed
US-7504522-B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMITED (GB) 2009-03-17 US disclosed
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders VERNALIS RESEARCH LIMAITED (GB) 2007-03-08 US disclosed
EP-1620395-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2006-02-01 EP disclosed
WO-2004096763-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RESEARCH LIMITED (GB) 2004-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054891-A1 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders CNR1, CNR2, GPR119 CNR2 2/4885EPHX2 1008/4885POLB 4840/4885
US-20240000748-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH CNR2 2/4885EPHX2 898/4885POLB 2191/4885
US-20220151990-A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE CNR1, CNR2, FAAH CNR2 2/4885EPHX2 898/4885POLB 2191/4885
US-11141404-B1 Formulations and methods for treating acute cannabinoid overdose CNR1, CNR2, FAAH CNR2 2/4885EPHX2 898/4885POLB 2191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.