Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087457 | 0.82 | KLK7 (0.47) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4088557 | 0.82 | SMN1; SMN2 (0.48) | CDK7KDM4EKMT2AMAPK1GPR35 | |
| SCHEMBL4086303 | 0.80 | MAPK1 (0.49) | KDM4EKMT2AMAPK1NPC1RAB9A | |
| SCHEMBL4078720 | 0.79 | SMN1; SMN2 (0.46) | KDM4EKMT2AMAPK1NPC1RAB9A | |
| SCHEMBL4088564 | 0.79 | MAPT (0.48) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4081816 | 0.79 | MAPT (0.47) | KDM4EKMT2AMAPK1NPC1RAB9A | |
| SCHEMBL4089305 | 0.78 | NPC1 (0.42) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4083540 | 0.78 | FGFR1 (0.50) | CDK7KMT2AMAPK1GPR35HDAC6 | |
| SCHEMBL4088647 | 0.77 | PKM (0.46) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4078664 | 0.76 | HPGD (0.44) | CDK7GPR35HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |