Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078785 | 0.83 | AURKA (0.42) | KLK7RAB9ANPC1NR0B1PKM | |
| SCHEMBL4088557 | 0.83 | SMN1; SMN2 (0.48) | RAB9ANPC1MAPTPOLBHTT | |
| SCHEMBL4081816 | 0.82 | MAPT (0.47) | RAB9ANPC1PKMMAPTPOLB | |
| SCHEMBL4088564 | 0.82 | MAPT (0.48) | RAB9ANPC1PKMMAPTHSD17B10 | |
| SCHEMBL4078618 | 0.82 | CDK7 (0.35) | RAB9ANPC1NR0B1PKMMAPT | |
| SCHEMBL4083540 | 0.81 | FGFR1 (0.50) | RAB9ANPC1HTT | |
| SCHEMBL4089305 | 0.81 | NPC1 (0.42) | RAB9ANPC1MAPTPOLBTSHR | |
| SCHEMBL4086303 | 0.81 | MAPK1 (0.49) | RAB9ANPC1PKMMAPTPOLB | |
| SCHEMBL4088647 | 0.80 | PKM (0.46) | RAB9ANPC1PKMMAPTPOLB | |
| SCHEMBL4078720 | 0.80 | SMN1; SMN2 (0.46) | RAB9ANPC1PKMMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |