Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093027 | 0.85 | RAB9A (0.44) | TP53ALDH1A1L3MBTL1RAB9AAURKA | |
| SCHEMBL4088406 | 0.85 | ALDH1A1 (0.47) | KMT2ATP53ALDH1A1MEN1L3MBTL1 | |
| SCHEMBL4088217 | 0.85 | AURKA (0.51) | AURKAHTT | |
| SCHEMBL4083487 | 0.84 | SMN1; SMN2 (0.41) | KMT2ATP53ALDH1A1MEN1GAA | |
| SCHEMBL4093240 | 0.84 | AURKA (0.43) | AURKAUSP2 | |
| SCHEMBL4078482 | 0.83 | HPGD (0.46) | KMT2ATP53ALDH1A1MEN1RAB9A | |
| SCHEMBL4078785 | 0.83 | AURKA (0.42) | KMT2ATP53ALDH1A1MEN1GAA | |
| SCHEMBL4080830 | 0.83 | AURKA (0.41) | KMT2AMEN1GAARAB9AAURKA | |
| SCHEMBL4078750 | 0.81 | AURKA (0.45) | AURKAPARP1 | |
| SCHEMBL4088880 | 0.81 | AURKA (0.45) | KMT2ATP53ALDH1A1MEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |