Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078482 | 0.88 | HPGD (0.46) | SMN1; SMN2MAPK1AURKANPC1RAB9A | |
| SCHEMBL4080830 | 0.87 | AURKA (0.41) | SMN1; SMN2MAPK1AURKANPC1RAB9A | |
| SCHEMBL652230 | 0.86 | RXFP1 (0.42) | RXFP1MAPK1AURKAALDH1A1LMNA | |
| SCHEMBL4088406 | 0.86 | ALDH1A1 (0.47) | SMN1; SMN2MAPK1AURKANPC1RAB9A | |
| SCHEMBL4088217 | 0.85 | AURKA (0.51) | MAPK1AURKAHTT | |
| SCHEMBL655164 | 0.85 | AURKA (0.42) | SMN1; SMN2MAPK1AURKANPC1RAB9A | |
| SCHEMBL4083477 | 0.85 | AURKA (0.42) | SMN1; SMN2MAPK1AURKANPC1RAB9A | |
| SCHEMBL4082057 | 0.84 | KMT2A (0.44) | SMN1; SMN2AURKANPC1RAB9AHTT | |
| SCHEMBL4078720 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPK1ESR2NPC1RAB9A | |
| SCHEMBL4078785 | 0.84 | AURKA (0.42) | SMN1; SMN2MAPK1AURKANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |