Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086360 | 0.87 | MAPK1 (0.47) | RAB9AAURKANPC1SMN1; SMN2 | |
| SCHEMBL4078785 | 0.87 | AURKA (0.42) | RAB9ATP53KDM4EAURKAHTT | |
| SCHEMBL4088217 | 0.86 | AURKA (0.51) | AURKAHTT | |
| SCHEMBL4082057 | 0.85 | KMT2A (0.44) | RAB9ATP53USP2GFERAURKA | |
| SCHEMBL4078482 | 0.85 | HPGD (0.46) | RAB9ATP53KDM4EAURKAHTT | |
| SCHEMBL4083114 | 0.85 | AURKA (0.41) | RAB9ATP53AURKANPC1SMN1; SMN2 | |
| SCHEMBL4088406 | 0.85 | ALDH1A1 (0.47) | RAB9ATP53KDM4EAURKANPC1 | |
| SCHEMBL4083789 | 0.84 | EGLN1 (0.42) | AURKACYP2D6 | |
| SCHEMBL4092679 | 0.84 | AURKA (0.49) | RAB9AKDM4EAURKANPC1SMN1; SMN2 | |
| SCHEMBL4083886 | 0.83 | AURKA (0.44) | RAB9ATP53AURKANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |