Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083487 | 0.88 | SMN1; SMN2 (0.41) | HPGDAURKANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4088406 | 0.87 | ALDH1A1 (0.47) | HPGDAURKANPC1RAB9AMAPT | |
| SCHEMBL4078785 | 0.87 | AURKA (0.42) | HPGDAURKANPC1RAB9AMAPT | |
| SCHEMBL4088217 | 0.86 | AURKA (0.51) | AURKAMAPK1HTT | |
| SCHEMBL4083477 | 0.86 | AURKA (0.42) | HPGDAURKANPC1RAB9AMAPT | |
| SCHEMBL655164 | 0.86 | AURKA (0.42) | AURKANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL652230 | 0.85 | RXFP1 (0.42) | HPGDAURKAALDH1A1POLBLMNA | |
| SCHEMBL4093027 | 0.85 | RAB9A (0.44) | HPGDAURKANPC1RAB9AMAPT | |
| SCHEMBL4083278 | 0.84 | AURKA (0.42) | HPGDAURKANPC1RAB9AMAPT | |
| SCHEMBL4093020 | 0.84 | CDC7 (0.44) | AURKANPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |