Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086291 | 0.94 | MAPK1 (0.44) | RAB9ALMNAMAPTTSHRMAPK1 | |
| SCHEMBL4083518 | 0.94 | LMNA (0.44) | RAB9ALMNAMAPTTSHRMAPK1 | |
| SCHEMBL4093445 | 0.93 | LMNA (0.44) | RAB9ALMNAMAPTTSHRMAPK1 | |
| SCHEMBL4088668 | 0.92 | SMN1; SMN2 (0.54) | RAB9ALMNAMAPTTSHRMAPK1 | |
| SCHEMBL4083005 | 0.89 | MAPT (0.44) | RAB9AMAPTTSHRSMN1; SMN2BTK | |
| SCHEMBL4088637 | 0.86 | ALDH1A1 (0.43) | RAB9ALMNAMAPTTSHRSMN1; SMN2 | |
| SCHEMBL4083876 | 0.85 | KIT (0.45) | KDRMAPK14LCKMEN1KMT2A | |
| SCHEMBL4091779 | 0.85 | LMNA (0.44) | RAB9ALMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL4078418 | 0.84 | HTT (0.43) | RAB9ALMNAMAPTTSHRSMN1; SMN2 | |
| SCHEMBL1434223 | 0.84 | ABL1 (0.45) | BTKHDAC6KDRMAPK14HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |