Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3888747 | 0.93 | LMNA (0.43) | LMNANPSR1GPR35SMN1; SMN2MAPT | |
| SCHEMBL4088637 | 0.91 | ALDH1A1 (0.43) | LMNANPSR1GPR35SMN1; SMN2MAPT | |
| SCHEMBL4078418 | 0.91 | HTT (0.43) | LMNASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL4078227 | 0.90 | PAX8 (0.45) | LMNAGPR35SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4083509 | 0.90 | GPR35 (0.49) | LMNANPSR1GPR35SMN1; SMN2MAPT | |
| SCHEMBL4083134 | 0.89 | GPR35 (0.42) | GPR35SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL4078733 | 0.88 | ALDH1A1 (0.44) | LMNAGPR35SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4088619 | 0.88 | GPR35 (0.42) | GPR35MAPTALDH1A1HPGDRAB9A | |
| SCHEMBL4083252 | 0.86 | PTK2 (0.37) | LMNAGPR35SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4084033 | 0.86 | ELANE (0.45) | LMNAGPR35ALDH1A1ADORA3ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |