Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CLK3 | P49761 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083005 | 0.86 | MAPT (0.44) | KITFLT3MEN1KMT2AKDR | |
| SCHEMBL4083509 | 0.85 | GPR35 (0.49) | GPR35MEN1KMT2A | |
| SCHEMBL4082722 | 0.85 | RAB9A (0.43) | KITFLT3MEN1KMT2ALCK | |
| SCHEMBL4082122 | 0.84 | MCHR1 (0.42) | FLT3KDR | |
| SCHEMBL4088619 | 0.83 | GPR35 (0.42) | GPR35MEN1KMT2AMAPK14 | |
| SCHEMBL4083134 | 0.83 | GPR35 (0.42) | GPR35 | |
| SCHEMBL4088637 | 0.83 | ALDH1A1 (0.43) | GPR35KMT2A | |
| SCHEMBL4091779 | 0.83 | LMNA (0.44) | GPR35KMT2A | |
| SCHEMBL4078418 | 0.83 | HTT (0.43) | MEN1KMT2AMAOB | |
| SCHEMBL4086291 | 0.82 | MAPK1 (0.44) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |