Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093445 | 0.99 | LMNA (0.44) | LMNAMAPK1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL4086291 | 0.98 | MAPK1 (0.44) | LMNAMAPK1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL4082722 | 0.94 | RAB9A (0.43) | LMNAMAPK1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL4088668 | 0.94 | SMN1; SMN2 (0.54) | LMNAMAPK1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL4082122 | 0.89 | MCHR1 (0.42) | MAPTTSHRL3MBTL1HRH3MCHR1 | |
| SCHEMBL4088637 | 0.88 | ALDH1A1 (0.43) | LMNASMN1; SMN2RAB9AMAPTTSHR | |
| SCHEMBL4091779 | 0.86 | LMNA (0.44) | LMNASMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL4078418 | 0.86 | HTT (0.43) | LMNASMN1; SMN2RAB9AMAPTTSHR | |
| SCHEMBL4083509 | 0.85 | GPR35 (0.49) | LMNASMN1; SMN2RAB9AMAPTL3MBTL1 | |
| SCHEMBL4091205 | 0.85 | LRRK2 (0.46) | LMNAMAPK1SMN1; SMN2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |