Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 7/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880690 | 0.93 | MAPT (0.46) | MAPTHSD17B10HPGDTSHRTAAR1 | |
| SCHEMBL4091205 | 0.93 | LRRK2 (0.46) | MAPTHPGDTSHRAURKAMEN1 | |
| SCHEMBL4082722 | 0.89 | RAB9A (0.43) | MAPTTSHRMEN1KMT2AFLT3 | |
| SCHEMBL4083876 | 0.86 | KIT (0.45) | MEN1KMT2AFLT3KDRKIT | |
| SCHEMBL3880434 | 0.86 | LRRK2 (0.47) | MAPTHPGDAURKAMEN1KMT2A | |
| SCHEMBL654864 | 0.86 | SIRT6 (0.42) | MAPTRAB9A | |
| SCHEMBL4088637 | 0.85 | ALDH1A1 (0.43) | MAPTHPGDTSHRKMT2ANPC1 | |
| SCHEMBL4091779 | 0.85 | LMNA (0.44) | MAPTHPGDKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL4078418 | 0.85 | HTT (0.43) | MAPTHPGDTSHRMEN1KMT2A | |
| SCHEMBL4083509 | 0.85 | GPR35 (0.49) | MAPTHPGDMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |