Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.43 |
| ▸ | INSR | P06213 | 11/20 | 0.43 |
| ▸ | IGF1R | P08069 | 7/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 2/20 | 0.41 |
| ▸ | ROS1 | P08922 | 2/20 | 0.41 |
| ▸ | FER | P16591 | 2/20 | 0.41 |
| ▸ | LTK | P29376 | 2/20 | 0.41 |
| ▸ | FRK | P42685 | 2/20 | 0.41 |
| ▸ | MST1R | Q04912 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653322 | 0.89 | ALK (0.54) | AURKAKITFLT3ALKINSR | |
| SCHEMBL4082899 | 0.87 | AURKA (0.60) | AURKAKITFLT3ALKINSR | |
| SCHEMBL652599 | 0.86 | MEN1 (0.41) | — | |
| SCHEMBL4093460 | 0.79 | AURKA (0.48) | AURKAKITFLT3ALKINSR | |
| SCHEMBL653335 | 0.77 | FADS1 (0.36) | AURKAALKINSRIGF1RKDR | |
| SCHEMBL4082088 | 0.77 | SMN1; SMN2 (0.41) | ABL1 | |
| SCHEMBL4086497 | 0.77 | AURKA (0.71) | AURKAKITFLT3ABL1 | |
| SCHEMBL4084047 | 0.76 | AURKA (0.42) | AURKANTRK1FGFR1FGFR3CDK7 | |
| SCHEMBL653354 | 0.76 | RXFP1 (0.38) | KIT | |
| SCHEMBL652262 | 0.76 | AURKA (0.54) | AURKAKITFLT3ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |
| EP-2051981-B1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-08-25 | — | — | EP | disclosed |
| US-20090239924-A1 | 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-09-24 | — | — | US | disclosed |
| EP-2051981-A1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007138017-A1 | 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239924-A1 | 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | IGF1R, CDK1, CDK15 | AURKA 5/4885KIT 695/4885FLT3 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.