Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | PKM | P14618 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083487 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL4081816 | 0.84 | MAPT (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1PKM | |
| SCHEMBL2904998 | 0.81 | GPR35 (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL4088557 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL4087457 | 0.80 | KLK7 (0.47) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL4086303 | 0.80 | MAPK1 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1PKM | |
| SCHEMBL4078618 | 0.79 | CDK7 (0.35) | SMN1; SMN2NPC1RAB9AHTTPKM | |
| SCHEMBL2913699 | 0.79 | GPR35 (0.51) | NPC1RAB9AHTTALDH1A1PKM | |
| SCHEMBL2912045 | 0.78 | CYP1A2 (0.42) | HTTALDH1A1HPGDMAPK1CYP2C9 | |
| SCHEMBL4083540 | 0.78 | FGFR1 (0.50) | NPC1RAB9AHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |