Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092679 | 0.91 | AURKA (0.49) | HDAC6AURKAMAPK1CDK2B3GNT2 | |
| SCHEMBL4088609 | 0.91 | AURKA (0.49) | HDAC6AURKACDK2CCNA2CCNA1 | |
| SCHEMBL4088217 | 0.84 | AURKA (0.51) | HDAC6AURKAMAPK1CDK2CCNA2 | |
| SCHEMBL4088416 | 0.83 | LMNA (0.42) | AURKAMAPK1NPC1RAB9AKCNMA1 | |
| SCHEMBL4082950 | 0.82 | AURKA (0.44) | AURKAMAPK1CDK2CCNA2CCNA1 | |
| SCHEMBL4082917 | 0.80 | AURKA (0.48) | HDAC6AURKACDK2CCNA2CCNA1 | |
| SCHEMBL4091567 | 0.80 | AURKA (0.48) | AURKAROCK2FLT3NPC1RAB9A | |
| SCHEMBL4083473 | 0.80 | PDE2A (0.47) | HDAC6AURKAMAPK1FLT3NPC1 | |
| SCHEMBL4086381 | 0.80 | FLT3 (0.42) | HDAC6AURKACDK2CCNA2CCNA1 | |
| SCHEMBL4085444 | 0.80 | AURKA (0.47) | HDAC6AURKALRRK2CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |