Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147866 | 0.87 | HSD11B1 (0.32) | — | |
| SCHEMBL1344006 | 0.84 | HSP90AA1 (0.32) | — | |
| SCHEMBL4077177 | 0.72 | KDM4E (0.39) | KCNMA1ALDH1A1 | |
| SCHEMBL3973590 | 0.70 | KCNMA1 (0.38) | KCNMA1ALDH1A1KMT2A | |
| SCHEMBL4088457 | 0.70 | KCNMA1 (0.36) | KCNMA1 | |
| SCHEMBL3974423 | 0.69 | KDM4E (0.36) | KCNMA1ALDH1A1KMT2A | |
| SCHEMBL1148455 | 0.68 | HSD11B1 (0.32) | KCNMA1 | |
| SCHEMBL5329381 | 0.68 | TRPA1 (0.40) | KCNMA1ALDH1A1 | |
| SCHEMBL3973703 | 0.68 | KCNN4 (0.37) | KCNMA1ALDH1A1 | |
| SCHEMBL4089989 | 0.68 | MGAM (0.35) | KCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |