Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SI | P14410 | 2/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148407 | 0.84 | GAA (0.36) | MGAMGAASIMGAM2BTK | |
| SCHEMBL3973590 | 0.76 | KCNMA1 (0.38) | GAAKCNMA1KCNN4 | |
| SCHEMBL5329381 | 0.75 | TRPA1 (0.40) | MGAMGAASIMGAM2KCNMA1 | |
| SCHEMBL3973703 | 0.73 | KCNN4 (0.37) | GAAKCNMA1KCNN4 | |
| SCHEMBL3974423 | 0.72 | KDM4E (0.36) | KCNMA1 | |
| SCHEMBL4088457 | 0.71 | KCNMA1 (0.36) | KCNMA1 | |
| SCHEMBL5369428 | 0.70 | GABRA1 (0.37) | HTR2CKCNMA1 | |
| SCHEMBL3974239 | 0.69 | KCNMA1 (0.36) | KCNMA1 | |
| SCHEMBL3972617 | 0.69 | NPC1 (0.38) | GAA | |
| SCHEMBL4077177 | 0.68 | KDM4E (0.39) | GAAKCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |