Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651483 | 0.94 | EGLN1 (0.40) | EGLN1AURKAMAPK1ADORA3ANO1 | |
| SCHEMBL4086360 | 0.90 | MAPK1 (0.47) | EGLN1AURKAMAPK1ANO1ABL1 | |
| SCHEMBL4083114 | 0.86 | AURKA (0.41) | AURKAMAPK1ANO1ABL1BCR | |
| SCHEMBL4088217 | 0.85 | AURKA (0.51) | AURKAMAPK1ABL1BCRUSP36 | |
| SCHEMBL4093027 | 0.84 | RAB9A (0.44) | AURKACYP2D6 | |
| SCHEMBL4088455 | 0.84 | AURKA (0.47) | EGLN1AURKAMAPK1ADORA3ABL1 | |
| SCHEMBL4092674 | 0.84 | AURKA (0.43) | EGLN1AURKAMAPK1ANO1ABL1 | |
| SCHEMBL4092679 | 0.83 | AURKA (0.49) | AURKAMAPK1ADORA3ABL1BCR | |
| SCHEMBL4083886 | 0.83 | AURKA (0.44) | EGLN1AURKAMAPK1ABL1BCR | |
| SCHEMBL2910927 | 0.82 | GRM4 (0.39) | EGLN1AURKAMAPK1CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |