Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086360 | 0.89 | MAPK1 (0.47) | AURKAUSP36MAPK1NPC1RAB9A | |
| SCHEMBL4088217 | 0.86 | AURKA (0.51) | AURKAUSP36MAPK1ABL1BCR | |
| SCHEMBL4083789 | 0.86 | EGLN1 (0.42) | AURKAUSP36MAPK1ANO1ABL1 | |
| SCHEMBL4093027 | 0.85 | RAB9A (0.44) | AURKAALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL4092679 | 0.84 | AURKA (0.49) | AURKAUSP36LMNAMAPTMAPK1 | |
| SCHEMBL4083886 | 0.83 | AURKA (0.44) | AURKAUSP36LMNAL3MBTL1TP53 | |
| SCHEMBL4088455 | 0.83 | AURKA (0.47) | AURKAUSP36MAPK1NPC1HPGD | |
| SCHEMBL4078785 | 0.83 | AURKA (0.42) | AURKAALDH1A1LMNAMAPTTP53 | |
| SCHEMBL4088406 | 0.83 | ALDH1A1 (0.47) | AURKAALDH1A1USP36MAPTL3MBTL1 | |
| SCHEMBL4088680 | 0.83 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTTHRBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |