SCHEMBL4085978

SCHEMBL4085978

N#Cc1cccc2c(N)cccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.59
CYP3A4 P08684 3/20 0.59
TSHR P16473 3/20 0.59
HPGD P15428 2/20 0.59
HSD17B10 Q99714 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
NR4A2 P43354 1/20 0.46
KEAP1 Q14145 1/20 0.44
KDM4E B2RXH2 2/20 0.44
MAPT P10636 2/20 0.44
GAA P10253 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
IMPDH2 P12268 1/20 0.42
IMPDH1 P20839 1/20 0.42
PNMT P11086 1/20 0.42
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30881802 1.00 ALDH1A1 (0.59) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL31588265 1.00 ALDH1A1 (0.59) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL30175215 0.86 IMPDH2 (0.52) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL630084 0.86 IMPDH2 (0.52) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL29489124 0.85 CA1 (0.54) ALDH1A1TSHRKDM4EMAPTGAA
SCHEMBL45954 0.85 CA1 (0.54) ALDH1A1TSHRKDM4EMAPTGAA
SCHEMBL9669834 0.81 PNMT (0.42) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL19072727 0.81 AR (0.47) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL9746966 0.80 PNMT (0.52) ALDH1A1TSHRKDM4EMAPTGAA
SCHEMBL11228244 0.80 IMPDH2 (0.59) ALDH1A1TSHRKDM4EMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170159189-A1 METHOD FOR PRODUCING 1,5-DIAMINONAPHTHALENE AND 1-AMINO-5-NITRONAPHTHALENE BY DIRECT ELECTROCHEMICAL AMINATION OF NON-ACTIVATED OR DEACTIVATED AROMATIC SYSTEMS ON BORON-DOPED DIAMOND ANODES COVESTRO DEUTSCHLAND AG (DE) 2017-06-08 US claimed
CN-106414391-A Method for producing 1.5-diaminonaphthalene and 1-amino-5-nitronaphthalene by direct electrochemical amination of non-activated or deactivated aromatic systems on boron-doped diamond anodes 科思创德国股份有限公司 2017-02-15 CN claimed
CN-102924330-A Method for large-scale preparation of 5-amino-1-naphthyl nitrile UNIV EAST CHINA SCIENCE & TECH 2013-02-13 CN claimed
CN-118026880-A Aryl amide compound, pharmaceutical composition containing same and application thereof 华东师范大学 2024-05-14 CN disclosed
US-20230365563-A1 QUINAZOLINE COMPOUND AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2023-11-16 US disclosed
US-20230365563-A1 QUINAZOLINE COMPOUND AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2023-11-16 US disclosed
EP-4223761-A1 QUINAZOLINE COMPOUND AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-08-09 EP disclosed
CN-106414391-B Method by making aromatic systems Direct Electrochemistry amination that is unactivated or deactivating on boron-doped diamond anode to prepare 1,5- diaminonaphthalene and 1- amino -5- nitronaphthalene 科思创德国股份有限公司 2019-08-30 CN disclosed
EP-3143185-B1 METHOD FOR THE ELECTROCHEMICAL AMINATION AT BORON DOPED DIAMOND ANODES COVESTRO DEUTSCHLAND AG (DE) 2018-10-03 EP disclosed
US-20170159189-A1 METHOD FOR PRODUCING 1,5-DIAMINONAPHTHALENE AND 1-AMINO-5-NITRONAPHTHALENE BY DIRECT ELECTROCHEMICAL AMINATION OF NON-ACTIVATED OR DEACTIVATED AROMATIC SYSTEMS ON BORON-DOPED DIAMOND ANODES COVESTRO DEUTSCHLAND AG (DE) 2017-06-08 US disclosed
EP-3143185-A1 METHOD FOR PRODUCING 1.5-DIAMINONAPHTHALENE AND 1-AMINO-5-NITRONAPHTHALENE BY DIRECT ELECTROCHEMICAL AMINATION OF NON-ACTIVATED OR DEACTIVATED AROMATIC SYSTEMS ON BORON-DOPED DIAMOND ANODES Covestro Deutschland AG (DE) 2017-03-22 EP disclosed
WO-2005049023-A1 GLYT1 TRANSPORTER INHIBITORS GLAXO GROUP LIMITED (GB) 2005-06-02 WO disclosed
EP-1455777-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM PLC (GB) 2004-09-15 EP disclosed
WO-2003055478-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-10 WO disclosed
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP disclosed
EP-0975593-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2000-02-02 EP disclosed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO disclosed
WO-1998050358-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed
US-4237019-A PROTECTING AQUEOUS MEDIUM SUCH AS WATER BASED PAINTS OR METAL WORKING FLUIDS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-12-02 US disclosed
US-4008326-A INCREASING PRODUCTION OF PROSTAGLANDINS THE UPJOHN COMPANY (US) 1977-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230365563-A1 QUINAZOLINE COMPOUND AND APPLICATION THEREOF KRAS, NRAS, BRAF ALDH1A1 3174/4885CYP3A4 710/4885TSHR 4687/4885
US-20170159189-A1 METHOD FOR PRODUCING 1,5-DIAMINONAPHTHALENE AND 1-AMINO-5-NITRONAPHTHALENE BY DIRECT ELECTROCHEMICAL AMINATION OF NON-ACTIVATED OR DEACTIVATED AROMATIC SYSTEMS ON BORON-DOPED DIAMOND ANODES DAO, APEX1, DDAH1 ALDH1A1 430/4885CYP3A4 212/4885TSHR 3769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.