Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850061 | 0.88 | AURKA (0.46) | KMT2AMEN1MAPTTP53ALDH1A1 | |
| SCHEMBL4083197 | 0.87 | SMN1; SMN2 (0.41) | KMT2AMEN1MAPTTP53ALDH1A1 | |
| SCHEMBL4082088 | 0.87 | SMN1; SMN2 (0.41) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL4088294 | 0.85 | RAB9A (0.41) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL4088416 | 0.84 | LMNA (0.42) | KMT2AMEN1MAPTTP53KDM4E | |
| SCHEMBL651489 | 0.82 | RXFP1 (0.47) | APLNRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4093020 | 0.81 | CDC7 (0.44) | MAPTTP53RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4086290 | 0.80 | MAPT (0.40) | KMT2AMEN1MAPTTP53ALDH1A1 | |
| SCHEMBL739810 | 0.80 | APLNR (0.47) | APLNRKMT2AMEN1MAPTTP53 | |
| SCHEMBL4083484 | 0.79 | SMN1; SMN2 (0.51) | KMT2AMEN1MAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |