SCHEMBL4086458

SCHEMBL4086458

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nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 3/20 0.50
MME P08473 6/20 0.45
SLC15A2 Q16348 1/20 0.41
NMT2 O60551 2/20 0.39
NMT1 P30419 2/20 0.39
CA2 P00918 3/20 0.38
CA1 P00915 2/20 0.38
QRFPR Q96P65 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29456599 1.00 TGFBR1 (0.50) TGFBR1MMESLC15A2NMT2NMT1
SCHEMBL29556650 0.92 TGFBR1 (0.57) TGFBR1MMECA2CA1
SCHEMBL783083 0.92 TGFBR1 (0.57) TGFBR1MMECA2CA1
SCHEMBL783082 0.92 TGFBR1 (0.57) TGFBR1MMECA2CA1
SCHEMBL30945534 0.92 ACE (0.45) TGFBR1MMESLC15A2NMT2NMT1
SCHEMBL29372719 0.90 TGFBR1 (0.42) TGFBR1MMESLC15A2NMT2NMT1
SCHEMBL29051061 0.90 MME (0.50) TGFBR1MMESLC15A2CA2
SCHEMBL29702215 0.90 ACE (0.50) TGFBR1MMESLC15A2NMT2NMT1
SCHEMBL29051058 0.90 MME (0.50) TGFBR1MMESLC15A2CA2
SCHEMBL31707359 0.88 TGFBR1 (0.47) TGFBR1MMESLC15A2CA2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11761956-B2 Nanopore biosensors for detection of proteins and nucleic acids KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-09-19 US claimed
US-20220154170-A1 PROTEIN RESIDUE MAPPING USING A COMBINATION OF DEEP MUTATIONAL SCANNING AND PHAGE DISPLAY HIGH THROUGHPUT SEQUENCING FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2022-05-19 US claimed
EP-4731652-A1 MULTI-SPECIFIC PROTEINACEOUS PRODRUG CONSTRUCTS Aarhus Universitet (DK) 2026-04-29 EP disclosed
US-12551549-B2 Methods of eliciting antibodies that bind to full-length glycosylated HIV-1 ENV using multimerized ENV cores FRED HUTCHINSON CANCER CENTER (US) 2026-02-17 US disclosed
US-20260041758-A1 IMMUNIZATION STRATEGIES TO MORE NATURALLY GUIDE THE MATURATION OF ANTIBODIES AGAINST HUMAN IMMMUNODEFICIENCY VIRUS (HIV) IN HIV-INFECTED SUBJECTS FRED HUTCHINSON CANCER CENTER (US) 2026-02-12 US disclosed
US-20250346874-A1 FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS DUKE UNIVERSITY (US) 2025-11-13 US disclosed
US-12422369-B2 Immunosensor PPB Technology Pty Ltd (AU) 2025-09-23 US disclosed
EP-4617286-A2 TREM2 ANTIGEN BINDING PROTEINS AND USES THEREOF Amgen Inc. (US) 2025-09-17 EP disclosed
US-20250224397-A1 BORRELIA IMMUNOASSAYS AND MATERIALS THEREFOR BIO RAD LABORATORIES INC (US) 2025-07-10 US disclosed
US-12351839-B2 Rationally-designed single-chain meganucleases with non-palindromic recognition sequences PRECISION BIOSCIENCES, INC. (US) 2025-07-08 US disclosed
WO-2025137325-A1 IMMUNIZATION SCHEDULES TO ELICIT BROADLY-NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMMUNODEFICIENCY VIRUS (HIV) FRED HUTCHINSON CANCER CENTER (US) 2025-06-26 WO disclosed
US-20220137047-A1 BORRELIA IMMUNOASSAYS AND MATERIALS THEREFOR BIO-RAD LABORATORIES, INC. 2022-05-05 US disclosed
WO-2022086450-A1 BACTERIAL MICROCOMPARTMENT VIRUS-LIKE PARTICLES NATIONAL UNIVERSITY OF SINGAPORE (SG) 2022-04-28 WO disclosed
CN-114341637-A Immunosensor 联邦科学工业研究组织 2022-04-12 CN disclosed
US-20220089657-A1 MODIFIED PEPTIDES SASINAPAS CO LTD (TH) 2022-03-24 US disclosed
EP-3963324-A1 IMMUNOSENSOR Commonwealth Scientific and Industrial Research Organisation (AU) 2022-03-09 EP disclosed
US-20220064623-A1 ENDOLYSIN VARIANT SASINAPAS CO., LTD. (TH) 2022-03-03 US disclosed
EP-3661954-B1 INTERLEUKIN-21 MUTEINS AND METHODS OF TREATMENT AMGEN INC (US) 2022-02-09 EP disclosed
US-8076285-B2 Lysobactin amides AICURIS GMBH & CO. KG (DE) 2011-12-13 US disclosed
US-20090203582-A1 LYSOBACTIN AMIDES BAYER HEALTHCARE AG (DE) 2009-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12551549-B2 Methods of eliciting antibodies that bind to full-length glycosylated HIV-1 ENV using multimerized ENV cores CD4, VSIG8, FCGR3B TGFBR1 3814/4885MME 2962/4885SLC15A2 3254/4885
US-12422369-B2 Immunosensor KLK3, CD47, FCGR3B TGFBR1 4249/4885MME 419/4885SLC15A2 3482/4885
US-20260041758-A1 IMMUNIZATION STRATEGIES TO MORE NATURALLY GUIDE THE MATURATION OF ANTIBODIES AGAINST HUMAN IMMMUNODEFICIENCY VIRUS (HIV) IN HIV-INFECTED SUBJECTS CD4, IGSF11, ICOS TGFBR1 1980/4885MME 1867/4885SLC15A2 805/4885
US-20090203582-A1 LYSOBACTIN AMIDES AADAT, HAMP, DLST TGFBR1 2913/4885MME 965/4885SLC15A2 344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.