Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 5/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL74204 | 0.68 | HCAR1 (0.46) | HCAR1PDE9APDE1APDE1BPDE1C | |
| SCHEMBL2662469 | 0.66 | SLC6A2 (0.49) | PDE9APDE1APDE1BPDE1CSLC6A2 | |
| SCHEMBL27760468 | 0.65 | HCAR1 (0.34) | HCAR1SCN9ASLC6A2SLC6A4 | |
| SCHEMBL6669542 | 0.61 | HCAR1 (0.40) | HCAR1SCN9AP2RX7KDM4ESLC6A2 | |
| SCHEMBL4078586 | 0.61 | L3MBTL1 (0.43) | HCAR1KDM4EHSD11B1 | |
| SCHEMBL26014646 | 0.60 | GABRA1 (0.43) | PDE9APDE1APDE1BPDE1CSLC6A2 | |
| SCHEMBL27446325 | 0.60 | KCNK3 (0.37) | HCAR1PDE9APDE1APDE1BPDE1C | |
| SCHEMBL23102232 | 0.60 | POLB (0.44) | SCN9AKDM4E | |
| SCHEMBL5906114 | 0.59 | HCAR1 (0.47) | HCAR1PDE9APDE1APDE1BPDE1C | |
| SCHEMBL16915166 | 0.59 | P2RX7 (0.46) | HCAR1SCN9AP2RX7SLC6A2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |