Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755316 | 0.83 | HCAR2 (0.36) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL4758299 | 0.80 | LMNA (0.42) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL4755372 | 0.79 | TSHR (0.39) | KMT2AMEN1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9831573 | 0.77 | PTGS2 (0.31) | ALDH1A1LMNA | |
| SCHEMBL3392997 | 0.68 | TDP1 (0.40) | KMT2AMEN1ATMSMN1; SMN2HTT | |
| SCHEMBL14237164 | 0.63 | SRD5A1 (0.42) | APPCA12CA1CA2CA7 | |
| SCHEMBL7980166 | 0.62 | APP (0.38) | APPKMT2AMEN1CA12CA1 | |
| 1,2-Dimethoxybenzene SCHEMBL27514430 | 0.62 | POLB (0.68) | KMT2AATMCA12CA1CA2 | |
| SCHEMBL11008245 | 0.62 | LMNA (0.39) | KMT2AMEN1POLBLMNA | |
| SCHEMBL20790150 | 0.62 | OPRM1 (0.50) | APPKMT2AMEN1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| EP-0163238-B1 | SUBSTITUTED AND BRIDGED PYRIDINES USEFUL AS PHARMACEUTICAL AGENTS | MERCK & CO. INC. (US) | 1991-07-24 | — | — | EP | disclosed |
| US-4579851-A | HYPOTENSIVE, ANTIARRHYTHMIA AGENTS | MERCK & CO., INC. (US) | 1986-04-01 | — | — | US | disclosed |