Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | USP8 | P40818 | 4/20 | 0.50 |
| ▸ | USP7 | Q93009 | 1/20 | 0.50 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094506 | 0.76 | RAB9A (0.49) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18122168 | 0.76 | MAPK13 (0.53) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8238836 | 0.76 | RAB9A (0.62) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL4259573 | 0.74 | RAB9A (0.47) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL29432454 | 0.74 | RAB9A (0.60) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7984580 | 0.74 | RAB9A (0.60) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7998771 | 0.74 | RAB9A (0.60) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL824427 | 0.72 | RAB9A (1.00) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL10050483 | 0.70 | USP8 (0.83) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14532729 | 0.69 | RAB9A (0.73) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181972-A1 | Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications | HYBRIGENICS SA (FR) | 2009-07-16 | — | — | US | claimed |
| EP-1798232-A1 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2007-06-20 | — | — | EP | claimed |
| US-20070135439-A1 | Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | US | claimed |
| EP-1963328-B1 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2013-10-30 | — | — | EP | disclosed |
| EP-1963328-B1 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2013-10-30 | — | — | EP | disclosed |
| US-20090181972-A1 | Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications | HYBRIGENICS SA (FR) | 2009-07-16 | — | — | US | disclosed |
| US-20090181972-A1 | Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications | HYBRIGENICS SA (FR) | 2009-07-16 | — | — | US | disclosed |
| US-7462615-B2 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2008-12-09 | — | — | US | disclosed |
| US-7462615-B2 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2008-12-09 | — | — | US | disclosed |
| EP-1963328-A2 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | Hybrigenics S.A. (FR) | 2008-09-03 | — | — | EP | disclosed |
| EP-1798232-A1 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2007-06-20 | — | — | EP | disclosed |
| EP-1798232-A1 | Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2007-06-20 | — | — | EP | disclosed |
| WO-2007066200-A2 | INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | WO | disclosed |
| US-20070135439-A1 | Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | US | disclosed |
| US-20070135439-A1 | Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | HYBRIGENICS SA (FR) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135439-A1 | Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications | SERPINB1, CTSF, CTSE | RAB9A 1952/4885MAPT 2097/4885SMN1; SMN2 4147/4885 |
| US-20090181972-A1 | Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications | SERPINB1, CTSF, CTSE | RAB9A 1952/4885MAPT 2097/4885SMN1; SMN2 4147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.