SCHEMBL824427

SCHEMBL824427

O=C1c2ccccc2-c2nc3ccccc3nc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 1.00
MAPT P10636 4/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
NPC1 O15118 3/20 1.00
ALDH1A1 P00352 3/20 1.00
AHR P35869 1/20 1.00
MAPK1 P28482 2/20 0.66
MEN1 O00255 3/20 0.62
KMT2A Q03164 3/20 0.62
HTT P42858 2/20 0.62
PKM P14618 1/20 0.62
RXFP1 Q9HBX9 1/20 0.62
TP53 P04637 1/20 0.62
USP8 P40818 3/20 0.60
USP7 Q93009 1/20 0.60
USP47 Q96K76 1/20 0.60
CDC25B P30305 1/20 0.48
PTPRC P08575 2/20 0.47
CTSL P07711 1/20 0.47
CTSS P25774 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1705356 0.93 RAB9A (0.88) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL2681287 0.85 RAB9A (0.74) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL2489961 0.85 MAPT (0.73) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL17333584 0.83 MAPT (0.70) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL14572522 0.82 RAB9A (0.69) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL14532729 0.82 RAB9A (0.73) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL16869836 0.82 RAB9A (0.68) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL21226345 0.82 RAB9A (0.68) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL14572513 0.82 RAB9A (1.00) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1
SCHEMBL6254319 0.82 RAB9A (1.00) RAB9AMAPTSMN1; SMN2NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160106743-A1 TOPOISOMERASE II POISONS AND METHODS OF MAKING AND USING SAME THE UNIVERSITY OF ROCHESTER (US) 2016-04-21 US claimed
US-4082750-A PHOTOSENSITIZERS, NITRATION RICOH CO., LTD. (JA) 1978-04-04 US claimed
US-20230265058-A1 CARBOXYLIC ACID OR CARBOXYLIC ACID ESTER COMPOUND HAVING FUSED-RING STRUCTURE, METHOD FOR PRODUCING THE SAME, AND USE OF COMPOUND FUJIFILM CORPORATION (JP) 2023-08-24 US disclosed
US-20230265058-A1 CARBOXYLIC ACID OR CARBOXYLIC ACID ESTER COMPOUND HAVING FUSED-RING STRUCTURE, METHOD FOR PRODUCING THE SAME, AND USE OF COMPOUND FUJIFILM CORPORATION (JP) 2023-08-24 US disclosed
WO-2023145663-A1 SOLVATE AND METHOD FOR MANUFACTURING SOLVATE 富士フイルム株式会社 2023-08-03 WO disclosed
US-20230183406-A1 COMPOUND, CURABLE RESIN COMPOSITION, CURED PRODUCT, OPTICAL MEMBER, AND LENS FUJIFILM CORPORATION (JP) 2023-06-15 US disclosed
US-11370744-B2 Compound, curable composition, cured product, optical member, and lens FUJIFILM CORPORATION (JP) 2022-06-28 US disclosed
US-20210299123-A1 SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-09-30 US disclosed
US-20200181061-A1 COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, OPTICAL MEMBER, AND LENS FUJIFILM CORPORATION (JP) 2020-06-11 US disclosed
EP-3261759-B1 SELF-HEALING CAPACITOR AND METHODS OF PRODUCTION THEREOF CAPACITOR SCIENCES INC (US) 2020-05-06 EP disclosed
US-20200131309-A1 PHASE DIFFERENCE FILM FUJIFILM CORPORATION (JP) 2020-04-30 US disclosed
US-20090161037-A1 Backlight Module and Liquid Crystal Display Incorporating the Same CRYSOPTIX KK (JP) 2009-06-25 US disclosed
US-20090161037-A1 Backlight Module and Liquid Crystal Display Incorporating the Same CRYSOPTIX KK (JP) 2009-06-25 US disclosed
WO-2009037565-A2 COLOUR LIQUID CRYSTAL DISPLAY AND PATTERNED COMPENSATION PANEL CRYSOPTIX K.K. (GB) 2009-03-26 WO disclosed
WO-2008142635-A2 COMPENSATED IN-PLANE SWITCHING MODE LIQUID CRYSTAL DISPLAY CRYSOPTIX KK (GB) 2008-11-27 WO disclosed
WO-2007141025-A2 LIQUID CRYSTAL DISPLAY OPERATING IN A VERTICALLY ALIGNED MODE CRYSOPTIX K.K. (JP) 2007-12-13 WO disclosed
WO-2007122389-A2 BACKLIGHT MODULE AND LIQUID CRYSTAL DISPLAY INCORPORATING THE SAME CRYSOPTIX K.K. (JP) 2007-11-01 WO disclosed
US-4148638-A ELECTROPHOTOGRAPHIC PLATE RICOH CO., LTD. (JP) 1979-04-10 US disclosed
US-4082750-A PHOTOSENSITIZERS, NITRATION RICOH CO., LTD. (JA) 1978-04-04 US disclosed
US-4082750-A PHOTOSENSITIZERS, NITRATION RICOH CO., LTD. (JA) 1978-04-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183406-A1 COMPOUND, CURABLE RESIN COMPOSITION, CURED PRODUCT, OPTICAL MEMBER, AND LENS POLR1A, RAD51, POLR2A RAB9A 3643/4885MAPT 419/4885SMN1; SMN2 587/4885
US-20230265058-A1 CARBOXYLIC ACID OR CARBOXYLIC ACID ESTER COMPOUND HAVING FUSED-RING STRUCTURE, METHOD FOR PRODUCING THE SAME, AND USE OF COMPOUND SPG11, HAT1, ASS1 RAB9A 3033/4885MAPT 1976/4885SMN1; SMN2 567/4885
US-20200181061-A1 COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, OPTICAL MEMBER, AND LENS CRYZ, CRYAA, WDR12 RAB9A 3444/4885MAPT 1212/4885SMN1; SMN2 2295/4885
US-20210299123-A1 SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF XIAP, BIRC5, TP53 RAB9A 2145/4885MAPT 3150/4885SMN1; SMN2 3055/4885
US-20160106743-A1 TOPOISOMERASE II POISONS AND METHODS OF MAKING AND USING SAME TOP2A, TOP2B, TOP1 RAB9A 3488/4885MAPT 3723/4885SMN1; SMN2 1196/4885
US-11370744-B2 Compound, curable composition, cured product, optical member, and lens CRYZ, CRYAA, WDR12 RAB9A 3444/4885MAPT 1212/4885SMN1; SMN2 2295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.